ar X iv : c on d - m at / 0 10 21 33 7 Fe b 20 01 Polymer Reptation and Nucleosome Repositioning

نویسنده

  • W. M. Gelbart
چکیده

We consider how beads can diffuse along a chain that wraps them, without becoming displaced from the chain; our proposed mechanism is analogous to the reptation of “stored length” in more familiar situations of polymer dynamics. The problem arises in the case of globular aggregates of proteins (histones) that are wound by DNA in the chromosomes of plants and animals; these beads (nucleosomes) are multiply wrapped and yet are able to reposition themselves over long distances, while remaining bound by the DNA chain. PACS numbers: 87.15.He, 36.20.Ey * Present address: Max-Planck-Institute for Polymer Research, Theory Group, POBox 3148, 55021 Mainz, Germany † Present address: Instituut-Lorentz for Theoretical Physics, Universiteit Leiden, Postbus 9506, 2300 RA Leiden, The Netherlands

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تاریخ انتشار 2014